Kliofem

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Kliofem on Prescriptsy

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What is Kliofem?

Kliofem is a continuous combined hormone replacement therapy (HRT) prescribed to relieve symptoms of the menopause.

In my clinical experience, women who are at least one year past their final menstrual period often find this particular formulation highly effective because it provides a steady dose of hormones, preventing the monthly withdrawal bleed that cyclical HRT causes.

Active Ingredient

This medication contains two active hormones: estradiol hemihydrate (2mg) and norethisterone acetate (1mg). The estradiol replaces the falling oestrogen levels, while the norethisterone protects the lining of the womb from overgrowth.

Indications

• Relief of severe menopausal symptoms (such as hot flushes, night sweats, and vaginal dryness) in women with an intact uterus.
• Prevention of postmenopausal osteoporosis in women at high risk of fractures who cannot tolerate other non-oestrogen treatments.

How to obtain Kliofem legally online?

You cannot legally purchase Kliofem without a prescription, as your cardiovascular and breast health must be evaluated before starting or continuing HRT.

However, you can obtain it without seeing your regular GP by using an online doctor service connected to a certified online pharmacy. Here is how the process works:

1. Step 1: Complete a medical questionnaire - You will fill out a detailed form about your medical history, current symptoms, and blood pressure readings.
2. Step 2: Doctor review - An EU-registered doctor will carefully assess your answers to ensure this HRT is clinically appropriate for you.
3. Step 3: Digital prescription issued - If approved, a digital prescription is sent directly to a partner pharmacy.
4. Step 4: Discreet delivery - The certified pharmacy dispenses and ships your medication securely to your home.

Dosage and Usage

The standard dosage for Kliofem is exactly one tablet taken daily.

In my practice, I always advise patients to take their tablet at the same time each day—whether that is with breakfast or before bed—to maintain steady hormone levels and minimise breakthrough bleeding.

• Take one 2mg/1mg tablet every day without a break between packs.
• Swallow the tablet whole with a glass of water.
• If you forget a dose and less than 12 hours have passed, take it immediately. If more than 12 hours have passed, discard the missed tablet and take your next dose at the normal time.

Kliofem is typically available in packs of 84 tablets (a 3-month supply) or 56 tablets. Missing doses increases the likelihood of irregular spotting, which is a common concern I hear from patients during their first few months of treatment.

Side Effects

Like all HRT, Kliofem can cause side effects. I frequently reassure my patients that many initial side effects, such as breast tenderness or minor spotting, often settle down after the first three months of use.

Common side effects

• Breast tenderness or enlargement
• Irregular vaginal bleeding or spotting (especially during the first 3-6 months)
• Headaches or migraines
• Weight fluctuations and fluid retention
• Mood changes or depressive symptoms

Rare side effects

• Blood clots in the legs (deep vein thrombosis) or lungs (pulmonary embolism)
• Gallbladder disease
• Increased risk of breast cancer (with long-term use)

When to contact a doctor?

You must stop taking Kliofem and seek immediate medical attention if you develop signs of a blood clot (such as painful swelling in your leg or sudden chest pain), notice new breast lumps, experience sudden severe headaches, or if your skin or eyes turn yellow (jaundice).

Important Warnings

Before starting any continuous combined HRT, a thorough medical history is essential. As a GP, I strictly monitor patients for cardiovascular and oncological risks before prescribing.

Contraindications

• Known, past, or suspected breast cancer
• Oestrogen-dependent tumours (such as endometrial cancer)
• Unexplained vaginal bleeding
• Untreated endometrial hyperplasia (thickening of the womb lining)
• Current or previous history of blood clots (venous thromboembolism)
• Active or recent liver disease where liver function tests have not returned to normal

Drug Interactions

Certain medications can interfere with how Kliofem works, potentially causing irregular bleeding or reducing its efficacy.

You must inform the EU-registered doctors if you are taking phenobarbital , phenytoin , or carbamazepine for epilepsy.

Similarly, antibiotics like rifampicin and herbal remedies containing St John's Wort can accelerate the breakdown of HRT hormones in your body.