Kliovance

How to order Kliovance

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3. Fill in a short health form.
4. A doctor reads your form.
5. If it is safe for you, they say yes.
6. Your order ships fast to your door.
7. It comes in a plain, sealed box.

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Kliovance on Prescriptsy

Kliovance is described on Prescriptsy as independent product information.

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What is Kliovance?

Kliovance is a continuous combined Hormone Replacement Therapy (HRT) prescribed to relieve symptoms of the menopause in women with an intact uterus who have not had a natural period for at least 12 months.

In my practice, I find continuous combined preparations like this particularly helpful for women who want to avoid the monthly withdrawal bleed associated with sequential HRT.

Active Ingredient

This medication contains two active hormones: estradiol ( 1mg ), which is identical to the estrogen naturally produced by women's ovaries, and norethisterone acetate ( 0.5mg ), a synthetic progestogen.

The addition of the progestogen is crucial as it protects the lining of the womb from overgrowth, which can occur if estrogen is taken alone.

Indications

• Relief of symptoms occurring after menopause, such as hot flushes, night sweats, and vaginal dryness
• Prevention of osteoporosis in postmenopausal women at high risk of future fractures who are intolerant of other medicinal products approved for osteoporosis prevention

How to obtain Kliovance legally online?

Many of my patients ask how they can safely access their HRT without long waits in a crowded waiting room.

You can arrange this through an online doctor service linked to a certified online pharmacy. The process is designed to ensure your safety while providing maximum convenience.

1. Step 1: Start your online consultation - You will fill out a comprehensive medical questionnaire detailing your menopausal symptoms, medical history, and blood pressure readings.
2. Step 2: Medical review - EU-registered doctors will review your answers to ensure this specific HRT is safe and appropriate for your individual health profile.
3. Step 3: Digital prescription issued - If approved, a digital prescription is generated automatically during your checkout process and sent directly to a partner pharmacy.
4. Step 4: Safe, legal and discreet delivery - The certified pharmacy dispenses and ships your medication securely to your door in unbranded packaging.

This medicine service ensures you receive genuine medication with proper medical oversight, without needing to visit your local surgery.

Dosage and Usage

The standard dosage for Kliovance is exactly one tablet taken once daily, at around the same time each day.

The available variant is the 1mg estradiol and 0.5mg norethisterone acetate combination, typically supplied in a pack of 84 tablets, which provides a 3-month supply.

• Take one tablet daily without taking a break between packs.
• Swallow the tablet whole with a glass of water.
• The medication can be taken with or without food.

As a GP, I always advise my patients to link taking their HRT to a daily habit, such as brushing their teeth in the morning, to avoid missed doses.

If you forget a tablet, take it as soon as you remember, unless it is more than 12 hours late.

In that case, simply skip the missed dose and take the next one as normal. Taking a double dose can significantly increase the likelihood of breakthrough bleeding.

Side Effects

Common side effects

• Breast tenderness or pain
• Breakthrough bleeding or spotting (very common in the first 3 to 6 months)
• Headaches
• Fluid retention leading to slight weight gain
• Abdominal pain or mild nausea

Rare side effects

• Blood clots in the legs or lungs (venous thromboembolism)
• Changes in liver function
• Migraine-like headaches (especially if you have never had them before)
• Increase in blood pressure

When to contact a doctor?

You should seek immediate medical attention if you develop signs of a blood clot, such as painful swelling in your leg, sudden chest pain, or difficulty breathing.

Also, contact a doctor urgently if you notice new breast lumps, experience a sudden and severe headache, or notice yellowing of your skin or eyes.

Additionally, while irregular bleeding is perfectly normal initially, please consult a doctor if it persists beyond the first six months of treatment or starts suddenly after a period of no bleeding.

Important Warnings

Contraindications

• Known, past, or suspected breast cancer
• Estrogen-dependent tumors, such as cancer of the womb lining
• Undiagnosed vaginal bleeding
• Untreated thickening of the womb lining (endometrial hyperplasia)
• History of blood clots, such as deep vein thrombosis or pulmonary embolism
• Active or recent liver disease

Drug Interactions

Certain medications can interfere with how HRT works, potentially causing irregular bleeding or reducing efficacy.

It is extremely important to declare if you are taking medications for epilepsy, such as phenobarbital , phenytoin , or carbamazepine .

Additionally, tuberculosis treatments like rifampicin or herbal remedies containing St John's Wort can increase the breakdown of the hormones in your body, making the treatment less effective.